Mutational Studies on 17β-HSD14, Serial Synchrotron X-ray Crystallography, Solubility Enhancement using Cyclodextrins and Fragment-Based Drug Discovery Multiple Blocks to Pave the Road of Drug Design
The first topic of this thesis (Chapter 2) presents a mutational study performed on 17β-hydroxysteroid dehydrogenase type 14 (17β-HSD14) S205 variant. Five different mutations were done with respect to five amino acids which are believed to have an essential role in the enzyme activity and assembly....
Inhibitoren im Komplex mit dem Protein Strukturbestimmung Kristallstrukturen 17b-HSD14 Fragment Screening crystallography, Inhibitor-Protein com
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26 (2022), 12 (2021)
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