Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

The data presented here show that different geometries of para-alkyl substituents of a benzenesulfonamide scaffold can have a significant influence on the thermodynamic and kinetic binding parameters and suggest, that the fine-tuning of the ligand geometry to match the geometry of the active site le...

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Bibliographic Details
Main Author: Glöckner, Steffen
Contributors: Klebe, Gerhard Prof. Dr. (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2020
Subjects:
Kinetik
Thermodynamics
Protein-Ligand-Wechselwirkungen
Wirkstoffdesign
Proteine
Isotherme Titrationskalorimetrie
Ligand
Isothermalk titration calorimetry
Drug design
Wirkstoff
Kinetics
Chemie
Wechselwirkung
Molekulardesign
Kristallographie
Mikrokalorimetrie
Proteinkristallographie
Protein-ligand interactions
Thermodynamik
Protein crystallography
Chemistry & allied sciences
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Call Number: urn:nbn:de:hebis:04-z2020-01231
Publication Date: 2020-12-22
Date of Acceptance: 2020-02-14
Downloads: 151 (2024), 159 (2023), 91 (2022), 55 (2021), 9 (2020)
License: https://creativecommons.org/licenses/by-nc-nd/4.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2020/0123
https://doi.org/10.17192/z2020.0123

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