Thermodynamic, Kinetic and Crystallographic Investigations of Benzenesulfonamides as Ligands of Human Carbonic Anhydrase II

The data presented here show that different geometries of para-alkyl substituents of a benzenesulfonamide scaffold can have a significant influence on the thermodynamic and kinetic binding parameters and suggest, that the fine-tuning of the ligand geometry to match the geometry of the active site le...

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Bibliographic Details
Main Author: Glöckner, Steffen
Contributors: Klebe, Gerhard Prof. Dr. (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2020
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Call Number: urn:nbn:de:hebis:04-z2020-01231
Downloads: 49 (2021), 9 (2020)
Publication Date: 2020-12-22
License: https://creativecommons.org/licenses/by-nc-nd/4.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2020/0123
https://doi.org/10.17192/z2020.0123