Structure-based protein engineering and biochemical investigations of fungal prenyltransferases for targeted production of novel prenylated indole alkaloids

Prenyltransferases (PTs) catalyze the transfer of one or more prenyl units with chain lengths of n x C5 (n = 1, 2 etc.) to diverse acceptors. Prenylations are essential in both the primary and secondary metabolism of all organisms. PTs are often involved in the biosynthetic pathways of secondary met...

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Bibliographic Details

Main Author:	Mai, Peter
Contributors:	Li, Shu-Ming (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2019
Subjects:	Pharmakologie, Therapeutik Prenyltransferases Dimethylallyl-Transferase DMATS DMAPP GPP FPP Friedel-Crafts Alkylation Enzyme Catalysis Ascomycota Indole Alkaloids Cycl Prenyltransferasen Dimethylallyl-Transferasen DMATS DMAPP GPP FPP Friedel-Crafts Alkylierung Enzymkatalyse Schlauchpilze Indolalkaloide Cycl Pharmacology & therapeutics, prescription drugs
Online Access:	PDF Full Text
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