Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

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Bibliographic Details
Main Author: Petrick, Joy Kristin
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
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Call Number: urn:nbn:de:hebis:04-z2019-05018
Publication Date: 2020-05-25
Date of Acceptance: 2019-09-12
Downloads: 26 (2024), 149 (2023), 183 (2022), 158 (2021), 49 (2020)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2019/0501
https://doi.org/10.17192/z2019.0501