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Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery

Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly affects underprivileged populations in South and Central America. The current standard of care for this disease are the two empirically discovered drugs benznidazole and nifurtimox. They show low efficacy, diffi...

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Bibliographic Details
Main Author: Petrick, Joy Kristin
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
Pharmakologie, Therapeutik
FDPS
kissing bug
Protein-Kristallograph
Fragment-basierte Wirkstoffforschung
isoprenoid
FPPS
protein cry
Isoprenoid
Farnesylpyroposphate-Synthase
Chagas disease
fragment based drug discovery
mevalonate
neglected disease
farnesyl pyrophosphate
Vernachlässigte Krankheit
Chagas
Pharmacology & therapeutics, prescription drugs
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