Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery

Trypanosoma brucei (T. brucei) is the causative agent of the Human African Trypanosomiasis (HAT), which is a neglected disease with an endemic occurrence in 36 sub-Saharan African countries. The current standard of care suffers from low efficacy and severe side effects. Therefore, new drugs with bet...

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Bibliographic Details

Main Author:	Münzker Lena
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2019
Subjects:	Trypanosoma brucei Pharmakologie, Therapeutik farnesyl pyrophosphate synthase Farnesylpyrophosphat-Synthase Fragment-basierte Wirkstoffentwicklung Fragment-based drug discovery Pharmacology & therapeutics, prescription drugs
Online Access:	PDF Full Text
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