Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

There are several biophysical methods developed to rapidly identify weakly binding fragments to a target protein. X-ray crystallography provides structural information that is crucial for fragment optimization, however there are several criteria that must be met for a successful fragment screening...

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Bibliographic Details

Main Author:	Hassaan, Engi
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2019
Subjects:	drug discovery x-ray crystallography comparative analysis NMR fragment screening peroxin 14 SPR tRNA guanine transglycosylase endothiapepsin Pharmakologie, Therapeutik Pharmacology & therapeutics, prescription drugs
Online Access:	PDF Full Text
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