Do All Roads Really Lead to Rome? Learnings from Comparative Analysis using SPR, NMR, & X-Ray Crystallography to Optimize Fragment Screening in Drug Discovery.

There are several biophysical methods developed to rapidly identify weakly binding fragments to a target protein. X-ray crystallography provides structural information that is crucial for fragment optimization, however there are several criteria that must be met for a successful fragment screening...

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Bibliographic Details
Main Author: Hassaan, Engi
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
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Call Number: urn:nbn:de:hebis:04-z2019-04915
Publication Date: 2020-11-24
Date of Acceptance: 2019-09-06
Downloads: 27 (2024), 84 (2023), 127 (2022), 39 (2021), 6 (2020)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2019/0491
https://doi.org/10.17192/z2019.0491