Synthetic lethal interactions between ATR and DNA polymerases as a novel concept for individualized cancer therapy

The chemical inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in different tumors. This effect is at least partly attributable to the synthetic lethal relationship between ATR and certain DNA repair genes. In a previous study of our lab...

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Bibliographic Details
Main Author: Job, Albert
Contributors: Gallmeier, Eike (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
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Call Number: urn:nbn:de:hebis:04-z2019-03830
Publication Date: 2019-08-28
Date of Acceptance: 2019-08-12
Downloads: 8 (2025), 143 (2024), 109 (2023), 81 (2022), 88 (2021), 59 (2020), 14 (2019)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2019/0383
https://doi.org/10.17192/z2019.0383