Die Regulation des nucleären Kalziumtransienten in ventrikulären Kardiomyozyten
Zusammengefasst stellt die Arbeit das cytoplasmatische Ca als Hauptdeterminante des nucleären Ca-Anstiegs heraus und liefert den Nachweis, dass die SERCA-Funktion die passive Ca-Propagation vom Cytoplasma in den Kern direkt moduliert. Darüber hinaus spielt die perinucleäre Ca-Beladung unter physiolo...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2019
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| Online Access: | PDF Full Text |
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In conclusion, this study reveals the cytoplasmic CaT as the most important determinant of the nuclear Ca increase and provides evidence that SERCA function directly modulates passive Ca propagation into the nucleus. Moreover, under physiological conditions, perinuclear Ca load only plays a minor role in the regulation of nuclear Ca. Finally, the major results from WKY rats could be reproduced in SHR, which confirmed the findings and provides an indication of their transferability and validity.