Establishment of new experimental models of progressive prodromal Parkinson’s disease using viral-mediated overexpression of wild-type human α-synuclein in the substantia nigra compacta and the locus coeruleus in mice

Establishment of new experimental models of progressive prodromal Parkinson’s disease using viral-mediated overexpression of wild-type human α-synuclein in the substantia nigra compacta and the locus coeruleus in mice

Part 1. Summary Alpha-7-nicotine-acetylcholine-receptor (α7-nAChR) agonists modulate the cholinergic anti-inflammatory pathway to attenuate proinflammatory signals and reduce dopaminergic neuronal cell loss in toxin-induced experimental murine models of Parkinson’s disease (PD). However, no researc...

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Bibliographic Details
Main Author: Lee, Bolam
Contributors: Oertel, Wolfgang (Prof. Dr. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2019
Subjects:
α-Synuclein
Parkinsonkrankheit
Medizin
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2019-01369
Publication Date: 2019-09-12
Date of Acceptance: 2019-02-08
Downloads: 53 (2024), 48 (2023), 58 (2022), 41 (2021), 31 (2020), 15 (2019)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2019/0136
https://doi.org/10.17192/z2019.0136

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