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Directed Evolution of an Fe(II)-Dependent Halogenase for Asymmetric C(sp3)-H Chlorination

Within this thesis, the chlorinase Wi-WelO15 from Westiella intricata UH strain HT-29-1 was explored for its evolvability towards non-natural substrates and its biocatalytic applicability. Organohalogens play an important role as pharmaceuticals and agricultural chemicals or synthetic intermediat...

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Main Author: Düwel, Sabine
Contributors: Höbenreich, Sabrina (Dr. rer. nat.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2018
Subjects:
biocatalysis
halogenase
gerichtete Evolution
Chemie
Biokatalyse
directed evolution
Halogenase
Chemistry & allied sciences
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Call Number: urn:nbn:de:hebis:04-z2018-05190
Publication Date: 2019-12-05
Date of Acceptance: 2018-12-19
Downloads: 74 (2025), 162 (2024), 155 (2023), 167 (2022), 251 (2021), 100 (2020), 1 (2019)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2018/0519
https://doi.org/10.17192/z2018.0519

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