Characterisation and differentiation of kinase binding pockets in PKA and PIM1 by small molecule fragments using protein crystallography
The primary aim of this thesis was the crystallographic analysis of PKA and Pim1 crystals in complex with small fragment-like molecules to identify potential fragment binders in the protein kinase binding pockets. In the first subproject of this thesis, the similarities and differences between both...
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Format: | Doctoral Thesis |
Language: | English |
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Philipps-Universität Marburg
2018
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Online Access: | PDF Full Text |
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