Influence of the in vivo half-antibody exchange on the therapeutic efficacy of an IgG4 antibody-drug conjugate

A high number of therapeutic antibodies and their derivates e.g. antibody-drug conjugates (ADC) are under preclinical or clinical evaluation for the treatment of cancer. Most of those ADCs are based on the IgG1 or IgG4 subtype, depending on whether additional effector functions are desired or not. I...

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Bibliographic Details
Main Author: Herbener, Peter
Contributors: Maier, Uwe G. (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2018
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Call Number: urn:nbn:de:hebis:04-z2018-01263
Publication Date: 2018-06-26
Date of Acceptance: 2018-06-05
Downloads: 15 (2024), 144 (2023), 93 (2022), 167 (2021), 219 (2020), 197 (2019), 50 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2018/0126
https://doi.org/10.17192/z2018.0126