Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

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Bibliographic Details

Main Author:	Bertoletti, Nicole
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2017
Subjects:	Inhibitor-Protein complex 17b-HSD14 Strukturbestimmung Inhibitoren im Komplex mit dem Protein crystallography, Fragment Screening Drug design Kristallstrukturen Biowissenschaften, Biologie Life sciences
Online Access:	PDF Full Text
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