Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

Structural Characterization of 17β-Hydroxysteroid Dehydrogenase Type 14 and Inhibitor Optimization Using Crystallography and Computational Techniques

17β-Hydroxysteroid dehydrogenase type 14 (17β-HSD14) is the latest identified subtype of 17β HSDs. In vivo this enzyme oxidizes the hydroxyl group at position 17 of estradiol (E2) and 5 androstenediol (5-diol) in the presence of NAD+ as cofactor. Two isoforms of this cytosolic protein exist that dif...

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Bibliographic Details
Main Author: Bertoletti, Nicole
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2017
Subjects:
Inhibitor-Protein complex
17b-HSD14
Strukturbestimmung
Inhibitoren im Komplex mit dem Protein
crystallography,
Fragment Screening
Drug design
Kristallstrukturen
Biowissenschaften, Biologie
Life sciences
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Call Number: urn:nbn:de:hebis:04-z2017-06718
Publication Date: 2018-05-07
Date of Acceptance: 2017-10-04
Downloads: 99 (2024), 121 (2023), 122 (2022), 158 (2021), 174 (2020), 94 (2019), 4 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2017/0671
https://doi.org/10.17192/z2017.0671

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