Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Over the last 20 years, the consideration of biophysical parameters such as kinetics and thermodynamics has been used to guide modern drug design. In contrast to the classical approach that mainly relies on affinity optimization, biophysical parameters allow a further discrimination of potential dru...

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Bibliographic Details
Main Author: Wienen-Schmidt, Barbara
Contributors: Klebe, Gerhard (Prof.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2017
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Online Access:PDF Full Text
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