Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Wienen-Schmidt, Barbara

Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

Over the last 20 years, the consideration of biophysical parameters such as kinetics and thermodynamics has been used to guide modern drug design. In contrast to the classical approach that mainly relies on affinity optimization, biophysical parameters allow a further discrimination of potential dru...

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Bibliographische Detailangaben
1. Verfasser:	Wienen-Schmidt, Barbara
Beteiligte:	Klebe, Gerhard (Prof.) (BetreuerIn (Doktorarbeit))
Format:	Dissertation
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2017
Schlagworte:	Protein Kinase A (PKA) Selektivität Fasudil Inhibition Pharmakologie, Therapeutik X-ray Crystallography Entropie NMR Thermodynamik Freiheitsgrad isothermal titration calorimetry (ITC) Röntgenstrukturanalyse Inhibitor Dynamik 15N- Kinases Enthalpie Kinase Dynamics Thermodynamics isotherme Titrationskalorimetrie (ITC) 15 Pharmacology & therapeutics, prescription drugs
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Beyond Affinity: Drug-Kinase Interaction Put under the Microscope

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