Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

In the pre-clinical development stages of most drug design campaigns, the equilibrium binding affinity of a prospective lead candidate, in the form of an IC50, Kd or ΔG° value, is the most commonly employed benchmark parameter for its effectiveness as a putative drug. Hydrogen bonding, van der Waals...

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Bibliographic Details

Main Author:	Cramer, Jonathan
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2017
Subjects:	SPR Thermodynamik Thermolysin Synthese Phosphonamidat Kinetik Chemische Synthese Wirkstoff Phosphonamidate Kinetics ITC Proteine Thermodynamics Synthesis Bindungskinetik Chemie Chemistry & allied sciences
Online Access:	PDF Full Text
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