Inhibitor Synthesis and Biophysical Characterization of Protein–Ligand–Solvent Interactions An Analysis of the Thermodynamics and Kinetics of Ligand Binding to Thermolysin

In the pre-clinical development stages of most drug design campaigns, the equilibrium binding affinity of a prospective lead candidate, in the form of an IC50, Kd or ΔG° value, is the most commonly employed benchmark parameter for its effectiveness as a putative drug. Hydrogen bonding, van der Waals...

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Bibliographic Details
Main Author: Cramer, Jonathan
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2017
Subjects:
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Call Number: urn:nbn:de:hebis:04-z2017-04658
Publication Date: 2018-08-08
Date of Acceptance: 2017-06-09
Downloads: 68 (2024), 99 (2023), 58 (2022), 37 (2021), 24 (2020), 36 (2019), 11 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2017/0465
https://doi.org/10.17192/z2017.0465