The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness

The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness

Marburg virus (MARV) is a highly pathogenic virus that causes severe, often lethal diseases specifically in humans and non-human primates. In rodents MARV is non-pathogenic. However, sequential passaging of MARV in rodents results in selection of a rodent-lethal virus. Lofts et al. established a gui...

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Bibliographic Details
Main Author: Köhler, Alexander
Contributors: Becker, Stephan (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2017
Subjects:
Virologie
L
Biowissenschaften, Biologie
VP40
Virale Fitness
Adaption
virale Polymerase
Medizin
Matrix Protein
Marburg Virus
Life sciences
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Call Number: urn:nbn:de:hebis:04-z2017-03377
Publication Date: 2017-06-12
Date of Acceptance: 2017-05-10
Downloads: 101 (2024), 106 (2023), 97 (2022), 109 (2021), 122 (2020), 112 (2019), 40 (2018)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2017/0337
https://doi.org/10.17192/z2017.0337

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