The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness

Marburg virus (MARV) is a highly pathogenic virus that causes severe, often lethal diseases specifically in humans and non-human primates. In rodents MARV is non-pathogenic. However, sequential passaging of MARV in rodents results in selection of a rodent-lethal virus. Lofts et al. established a gui...

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Bibliographic Details
Main Author: Köhler, Alexander
Contributors: Becker, Stephan (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2017
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Call Number: urn:nbn:de:hebis:04-z2017-03377
Publication Date: 2017-06-12
Downloads: 84 (2022), 109 (2021), 122 (2020), 112 (2019), 40 (2018)
License: https://creativecommons.org/licenses/by-nc-sa/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2017/0337
https://doi.org/10.17192/z2017.0337