The species-specific effects of guinea pig adaptive mutations in Marburg virus VP40 and L on the protein’s functions and viral fitness

Marburg virus (MARV) is a highly pathogenic virus that causes severe, often lethal diseases specifically in humans and non-human primates. In rodents MARV is non-pathogenic. However, sequential passaging of MARV in rodents results in selection of a rodent-lethal virus. Lofts et al. established a gui...

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Bibliographic Details

Main Author:	Köhler, Alexander
Contributors:	Becker, Stephan (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2017
Subjects:	Virologie Virale Fitness Adaption Biowissenschaften, Biologie Matrix Protein L Medizin virale Polymerase Marburg Virus VP40 Life sciences
Online Access:	PDF Full Text
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