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Structure-Based Design of a Blood Coagulation Factor XIII Blocker

FXIII belongs to the family of transglutaminases, mainly catalyzing the cross-linking of proteins by formation of an isopetide bond between a glutamine and a lysine side chain. FXIII represents the last enzyme of the blood coagulation cascade providing final stability to the blood clot by cross-link...

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Main Author: Stieler, Martin
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2017
Subjects:
Anticoagulants
Antikoagulans
Medical Chemistry
Blood Coagulation
Medizinische Chemie
Transglutaminases
Blutgerinnung
Transglutaminasen
Pharmakologie, Therapeutik
Faktor XIII
Factor XIII
Pharmacology & therapeutics, prescription drugs
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Call Number: urn:nbn:de:hebis:04-z2017-00819
Publication Date: 2017-02-23
Date of Acceptance: 2017-02-23
Downloads: 69 (2025), 118 (2024), 80 (2023), 115 (2022), 99 (2021), 105 (2020), 67 (2019), 33 (2018)
License: https://creativecommons.org/licenses/by/4.0
Access URL: https://archiv.ub.uni-marburg.de/diss/z2017/0081
https://doi.org/10.17192/z2017.0081

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