From Active-Site Mapping to Lead Discovery using Fragment-based Approaches on the Aspartic protease Endothiapepsin

The work focuses on the evaluation and comparison of different fragment-based approaches, for which purpose the model system Endothiapepsin (EP) has been used. The enzyme belongs to the family of aspartic proteases. We used the 361-entry in-house fragment library compiled with physico-chemical pro...

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Bibliographic Details

Main Author:	Radeva, Nedyalka
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2016
Subjects:	Screening Fragment Dynamic combinatorial chemistry X-Ray crystallography Technische Chemie Röntgenkristallographie Dynamische kombinatorische Chemie Chemical engineering
Online Access:	PDF Full Text
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