Towards Bioorthogonal Enzymatic Uncaging Reactions

In this thesis, engineered cytochrome P450 monooxygenase mutants are reported as highly active and selective catalysts for the bioorthogonal uncaging of diferent ether protected substrates, including the successful transfer of the uncaging reaction into living bacteria. This proof-of-principle study...

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Bibliographic Details

Main Author:	Ritter, Cornelia
Contributors:	Meggers, Eric (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2016
Subjects:	Bioorthogonal activation Enzym Schutzgruppe Chemische Biologie chemical biology Aktivierung Biowissenschaften, Biologie enzyme P450 caging Life sciences
Online Access:	PDF Full Text
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