Towards Bioorthogonal Enzymatic Uncaging Reactions

Towards Bioorthogonal Enzymatic Uncaging Reactions

In this thesis, engineered cytochrome P450 monooxygenase mutants are reported as highly active and selective catalysts for the bioorthogonal uncaging of diferent ether protected substrates, including the successful transfer of the uncaging reaction into living bacteria. This proof-of-principle study...

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Bibliographic Details
Main Author: Ritter, Cornelia
Contributors: Meggers, Eric (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2016
Subjects:
P450
caging
Enzym
Schutzgruppe
Chemische Biologie
Bioorthogonal
enzyme
Aktivierung
Biowissenschaften, Biologie
chemical biology
activation
Life sciences
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Summary:In this thesis, engineered cytochrome P450 monooxygenase mutants are reported as highly active and selective catalysts for the bioorthogonal uncaging of diferent ether protected substrates, including the successful transfer of the uncaging reaction into living bacteria. This proof-of-principle study points towards the utility of bioorthogonal enzyme/protecting group pairs for applications in the life sciences.
DOI:10.17192/z2016.0051

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