Metabolic changes in the brain as consequence of IL-1-induced hypoglycemia: involvement of MyD88

IL-1β induces a profound and long-lasting hypoglycemia in C57BL/6J mice (wild type, WT) and resets glucose homeostasis at central levels. Intracerebroventricular (i.c.v.) injection of IL-1 at a dose that has no effect when injected intraperitoneally (i.p.), induces hypoglycemia, even after a glucos...

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Bibliographic Details

Main Author:	Verdenhalven, Moritz
Contributors:	del Rey, Adriana (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2015
Subjects:	MyD88 IL-1 Medizin Neuroimmunologie Gehirn Brain Hypoglykämie hypoglycemia Medical sciences Medicine
Online Access:	PDF Full Text
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