Insights into Protein-Ligand Molecular Recognition: Thermodynamic, Kinetic and Structural Characterization of Inhibitor Binding to Aldose Reductase and Carbonic Anhydrase II

Insights into Protein-Ligand Molecular Recognition: Thermodynamic, Kinetic and Structural Characterization of Inhibitor Binding to Aldose Reductase and Carbonic Anhydrase II

Two pathological relevant proteins, human aldose reductase and human carbonic anhydrase, were used as model proteins to get insights into the process of molecular recognition. The thermodynamics and kinetics of the formation process of protein ligand complex formation were studied.

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Bibliographic Details
Main Author: Rechlin, Chris
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2015
Subjects:
Ligand
Medizin
Proteins
Kinetic
Drug Design
Kinetik
Thermodynamik
Arzneimitteldesign
Thermodynamic
Proteine
Medical sciences Medicine
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Zwei pathologisch relevante Proteine, die humane Aldose Reduktase und die humane Carboanhydrase, wurden als Modellproteine studiert um Einblick in den Prozess der molekularen Erkennung von Protein und Ligand zu gewinnen. The Thermodynamik und die Kinetik vo dem Bildungsprozess des Protein-Ligand-Komplexes wurden studiert.

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