Insights into Protein-Ligand Molecular Recognition: Thermodynamic, Kinetic and Structural Characterization of Inhibitor Binding to Aldose Reductase and Carbonic Anhydrase II

Two pathological relevant proteins, human aldose reductase and human carbonic anhydrase, were used as model proteins to get insights into the process of molecular recognition. The thermodynamics and kinetics of the formation process of protein ligand complex formation were studied.

Bibliographic Details

Main Author:	Rechlin, Chris
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2015
Subjects:	Ligand Medizin Proteins Kinetic Drug Design Kinetik Thermodynamik Arzneimitteldesign Thermodynamic Proteine Medical sciences Medicine
Online Access:	PDF Full Text
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