Synthesis, Identification, Kinetic, and Structural Characterization of Inhibitors of the Aspartic Proteases HTLV-1 Protease and Endothiapepsin

This thesis focuses on the identification and synthesis as well as kinetic and structural characterization of non-peptidic small molecule inhibitors of the two aspartic proteases HTLV-1 protease (HTLV-1 PR) and endothiapepsin. The HTLV-1 PR, a promising target for the treatment of viral infections...

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Bibliographic Details

Main Author:	Kuhnert, Maren Sophia
Contributors:	Diederich, Wibke (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2015
Subjects:	Indinavir Inhibitor enzyme inhibitor HTLV-1-Proteaseinhibitor aspartic proteases Enzym Proteinkristallographie Medizin X-ray crystallography Wirkstoffdesign drug design Proteasen Aspartylproteasen Medical sciences Medicine
Online Access:	PDF Full Text
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