Regulation of Rho-activating proteins by heterotrimeric G proteins: Sensitivity of Gα RhoGEF interaction is determined by dissociation kinetics

Activation of RhoGTPases downstream of G protein coupled receptors is important for many physiological functions, such as blood pressure regulation. The subfamilies Rho, Rac and Cdc42 are the best understood RhoGTPases and the present study focused on signaling towards the Rho subfamily member RhoA....

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Bibliographic Details

Main Author:	Bodmann, Eva-Lisa
Contributors:	Bünemann, Moritz (Prof.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2014
Subjects:	Biowissenschaften, Biologie Gα13 p63RhoGEF Leukämie assoziiertes RhoGEF Fluoreszenz-Resonanz-Energie-Transfer Regulator of G protein signaling 2 G-Protein gekoppelte Rezeptoren Gαq leukemia-associated RhoGEF Förster resonance energy transfer Life sciences
Online Access:	PDF Full Text
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