Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...

Full description

Bibliographic Details

Main Author:	Neeb, Manuel
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2014
Subjects:	drug design Wirkstoffdesign Transferase isothermal titration calorimetry Enzyminhibition Isothermale Titrationskalorimetrie X-ray crystallography Medizin Proteinkristallographie enzyme inhibition transferase Medical sciences Medicine
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!