Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...

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Bibliographic Details
Main Author: Neeb, Manuel
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2014
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Call Number: urn:nbn:de:hebis:04-z2014-04196
Publication Date: 2014-11-18
Date of Acceptance: 2014-11-05
Downloads: 47 (2024), 103 (2023), 120 (2022), 163 (2021), 126 (2020), 128 (2019), 98 (2018)
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