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Die Totalsynthese von Cladoniamid G und Cladoniamid F

Die Dissertation beschreibt die Totalsynthese der Naturstoffe Cladoniamid G und Cladoniamid F, die zur Gruppe der Indenotryptoline gehören und eng verwandt sind mit der Naturstoffklasse der Indolocarbazole. Schlüsselschritte der Synthese sind die Addition eines Indols an ein Mesoxalesteramid, die Su...

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Bibliographic Details
Main Author: Schütte, Julia
Contributors: Koert, Ulrich (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:German
Published: Philipps-Universität Marburg 2014
Subjects:
Natural Products
Indol
Naturwissenschaften
Indenotryptolines
Total Synthesis
Totalsynthese
Naturstoff
Indenotryptolin
Indolocarbazol
Natural sciences & mathematics
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This dissertation describes the total synthesis of two natural products cladoniamide G and cladoniamide F which belong to the group of indenotryptolines that is closely related to the natural product class of indolocarbazoles. Key steps of the synthesis were the addition of an indole to a mesoxalic ester amide, a Suzuki cross-coupling of two indoles and an intramolecular lactam formation. Additionally, a method for the enantioselective addtion of indoles to mesoxalic ester amides was developed.

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