PLZF/RARalpha binding partners and their influence on the induction of acute promyelocytic leukaemia

The acute promyelocytic leukaemia (APL) accounts for 10% of the adult AML patients. APL patients carry chromosomal translocations involving the rarα gene on chromosome 17. The most frequent translocations lead to the expression of the fusion proteins PML/RARα (98%; t(15;17)) and PLZF/RARα (1%; t(11;...

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Bibliographic Details

Main Author:	Frech, Miriam
Contributors:	Renkawitz-Pohl, Renate (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2014
Subjects:	Translokation high molecular weight complex Naturwissenschaften Chromosomenaberration Leukämie differentiation block acute promyelocytic leukaemia Akute myeloische Leukämie Natural sciences & mathematics
Online Access:	PDF Full Text
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