Interaction dynamics between heterotrimeric G-proteins and type V adenylyl cyclase determine sensitivity of effector regulation

Interaction dynamics between heterotrimeric G-proteins and type V adenylyl cyclase determine sensitivity of effector regulation

The signalling pathway from G-protein-coupled receptors to the second messenger cAMP is present in virtually all cells and of major physiological and pathophysiological importance. The membrane-spanning receptors can easily be targeted by pharmaceutical compounds and therapies to treat diseases like...

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Bibliographic Details
Main Author: Milde, Markus
Contributors: Bünemann, Moritz (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2013
Subjects:
Adenylylzyklase
Dynamik
G-protein
cAMP
FRET
Fluoreszenz-Resonanz-Energie-Transfer
adenylyl cyclase
Medizin
Interaktion
interaction
G-Protein
Medical sciences Medicine
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Call Number: urn:nbn:de:hebis:04-z2013-03902
Publication Date: 2013-08-14
Date of Acceptance: 2013-07-17
Downloads: 65 (2024), 59 (2023), 52 (2022), 63 (2021), 51 (2020), 49 (2019), 49 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2013/0390
https://doi.org/10.17192/z2013.0390

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