lin-Benzopurines as Inhibitors of tRNA-Guanine Transglycosylase: Perturbance of Homodimer Formation, Import of Water Clusters and Determinants of Crystallographical Disorder

In this thesis different methods of structure-based drug design have been applied to develop TGT inhibitors suiting the manifold purposes of the tackled projects. TGT is not only a putative target for the treatment of Shigellosis, but additionally represents a well-accessible model system to study m...

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Bibliographic Details
Main Author: Immekus, Florian Peter Philip
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2012
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Call Number: urn:nbn:de:hebis:04-z2013-00742
Publication Date: 2013-02-11
Date of Acceptance: 2013-01-30
Downloads: 57 (2024), 127 (2023), 114 (2022), 89 (2021), 120 (2020), 85 (2019), 62 (2018)
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