The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...

Full description

Bibliographic Details

Main Author:	Biela, Adam
Contributors:	Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2012
Subjects:	Thrombin Medizin ITC Thermolysin Water Network Wassernetzwerk Hydrophober Effekt Hydrophobic Effect Medical sciences Medicine
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!