Neuartige Metallkomplexe als Proteinkinaseinhibitoren
Diese Arbeit beschäftigt sich mit der Entwicklung neuer Pharmakophorliganden zur Darstellung verschiedener Metallkomplexe, die die ATP-Bindungstasche von Proteinkinasen adressieren und somit als ATP-kompetitive Inhibitoren wirken. Hierbei besetzt der neu entwickelte, planare Pharmakophorligand die A...
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| Format: | Doctoral Thesis |
| Language: | German |
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Philipps-Universität Marburg
2012
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| Online Access: | PDF Full Text |
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This thesis describes the design of new pharmacophore ligands and their metal complexes as ATP-competitive inhibitors of the ATP binding site of protein kinases. In these metal complexes the planar pharmacophore ligand occupies the adenine binding pocket of the kinase and the metal fragment addresses the ribose binding pocket. Following this strategy, three new classes of metallo-quinolinemaleimide, metallo-pyridylnaphthalimide and metallo-pyridylphthalimide inhibitors have been developed and investigated with respect to their coordination chemistry and their action as protein kinase inhibitors.