Nef from SIVmac239 down-modulates cell surface CXCR4 in tumor cells and inhibits proliferation, migration and angiogenesis

Aim: To evaluate if the lentiviral accessory protein Nef can down-regulate CXCR4 in tumor cells and affect tumor cell proliferation, migration and angiogenesis. Materials and Methods: HeLa-ACC cells were transfected with Nef from SIVmac239 and expression levels of cell surface CXCR4 were monitored b...

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Bibliographic Details
Main Author: Cai, Chengzhong
Contributors: Mandic, Robert (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2012
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Call Number: urn:nbn:de:hebis:04-z2011-08778
Publication Date: 2012-02-09
Date of Acceptance: 2012-01-06
Downloads: 29 (2024), 71 (2023), 112 (2022), 85 (2021), 62 (2020), 92 (2019), 47 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2011/0877
https://doi.org/10.17192/z2011.0877