Wertigkeit von CEA und CA 19-9 in verschiedenen Stadien des Harnblasenkarzinoms:serologische und immunhistochemische Ergebnisse

Das Karzinom der Harnblase ist neben dem Prostatakarzinom der häufigste urologische Tumor und zählt weltweit zu den häufigsten malignen Erkrankun-gen überhaupt. Bis zum heutigen Zeitpunkt existieren für das Harnblasenkarzinom keine zuverlässigen und routinemäßig eingesetzten Tumormarker, weder im R...

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Bibliographic Details
Main Author: Mecklenburg, Verena
Contributors: Hegele, A. (Dr.) (Thesis advisor)
Format: Doctoral Thesis
Published: Philipps-Universität Marburg 2011
Online Access:PDF Full Text
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Background: Reliable blood and urine markers for transitional cell carcinoma of the bladder (TCC) do not currently exist. The aim of this prospective study was the serological and immunohistochemical evaluation of CA19.9 and CEA in TCC and to assess the correlation with different TCC stages. Patients and Methods: CA19.9 and CEA levels were prospectively determined in samples from 231 patients with TCC suspected bladder lesions, before tran-surethral tumor resection. Additionally, these serum parameters were deter-mined in 9 patients with initial metastatic TCC. Immunohistochemical analysis on CA19.9 and CEA was performed in 83 patients. Results: Neither CA19.9 nor CEA levels were significantly elevated in TCC pa-tients. Patients with muscle-invasive TCC showed significantly higher levels of CEA (p=0.008) and CA19.9 (p<0.001) compared to those with superficial TCC. Significantly higher levels were also evident with increasing grade of malignan-cy. Metastatic TCC showed significantly elevated CA19.9 levels compared to muscle invasive TCC as well as locally advanced (pT3/pT4/pN+) compared to localized TCC (pT2/pN0). Immunohistochemical staining revealed a strong cor-relation between CA19.9 serum levels and staining intensity. Conclusion: CEA and CA19.9 are not useful markers in primary diagnosis of TCC. However, in instances of elevated CEA and CA19.9 levels where ga-strointestinal malignancy has been excluded, evidence of TCC should be sought. If elevated CEA and CA19.9 are present in TCC, serum levels correlate with tumor invasion and grade of malignancy.