Interferon regulatory factors 1 and 4 in T cell mediated immune modulation

The transcription factor interferon regulatory factor (IRF) 1 is essential for T helper cell 1 differentiation. Hereby, the respective Irf1 knockout mouse displays a severe immune defect and has an Th2 directed immune status per se. This effect is measurable by increased production of interleukin-4,...

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Bibliographic Details

Main Author:	Mahiny, Azita Josefine
Contributors:	Lohoff, Michael (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2011
Subjects:	Cre-lox knockout mouse IRF4 Biowissenschaften, Biologie Knockout-Maus T cells IRF1 T Zellen Life sciences
Online Access:	PDF Full Text
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