Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Holighaus, Yvonne

Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the nervous system, important for homeostatic responses to stress...

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Bibliographische Detailangaben
1. Verfasser:	Holighaus, Yvonne
Beteiligte:	Weihe, Eberhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format:	Dissertation
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2011
Schlagworte:	nervous system Nervensystem G protein-coupled receptors signal transduction Neuropeptide G-Protein gekoppelte Rezeptoren neuropharmacology Neuropharmakologie stress PACAP neuropeptides Signaltransduktion Naturwissenschaften Genexpression Stress gene expression Natural sciences & mathematics
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Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

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