Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the nervous system, important for homeostatic responses to stress...

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Bibliographic Details

Main Author:	Holighaus, Yvonne
Contributors:	Weihe, Eberhard (Prof. Dr.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2011
Subjects:	Nervensystem nervous system PACAP Neuropeptide neuropeptides G-Protein gekoppelte Rezeptoren gene expression Neuropharmakologie Signaltransduktion Naturwissenschaften Genexpression Stress stress G protein-coupled receptors neuropharmacology signal transduction Natural sciences & mathematics
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