Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the nervous system, important for homeostatic responses to stress...

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Bibliographische Detailangaben
1. Verfasser: Holighaus, Yvonne
Beteiligte: Weihe, Eberhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprache:Englisch
Veröffentlicht: Philipps-Universität Marburg 2011
Schlagworte:
nervous system
Nervensystem
G protein-coupled receptors
signal transduction
Neuropeptide
G-Protein gekoppelte Rezeptoren
neuropharmacology
Neuropharmakologie
stress
PACAP
neuropeptides
Signaltransduktion
Naturwissenschaften
Genexpression
Stress
gene expression
Natural sciences & mathematics
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Signatur: urn:nbn:de:hebis:04-z2011-05513
Publikationsdatum: 2011-08-29
Datum der Annahme: 2011-08-01
Downloads: 33 (2024), 55 (2023), 75 (2022), 124 (2021), 112 (2020), 151 (2019), 26 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2011/0551
https://doi.org/10.17192/z2011.0551

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