Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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Bibliographic Details
Main Author: Craan, Tobias Friedrich
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2011
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Call Number: urn:nbn:de:hebis:04-z2011-04293
Publication Date: 2011-06-28
Date of Acceptance: 2011-06-17
Downloads: 58 (2024), 87 (2023), 114 (2022), 124 (2021), 104 (2020), 229 (2019), 125 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2011/0429
https://doi.org/10.17192/z2011.0429