Towards Improved Aldose Reductase Inhibitors - Structural and Thermodynamic Investigation of Mutant and Wild Type Aldose Reductase Inhibitor Complexes

Rational drug design for flexible proteins like human aldose reductase comprises special challenges to find novel lead compounds or to improve known inhibitors. In this thesis, diverse aspects of the complexity of such a task were investigated to find promising new lead scaffolds and enhance the aff...

Full description

Bibliographic Details

Main Author:	Koch, Cornelia
Contributors:	Klebe, Gerhard (Prof.) (Thesis advisor)
Format:	Doctoral Thesis
Language:	English
Published:	Philipps-Universität Marburg 2011
Subjects:	Wirkstoffdesign drug design X-ray diabetes Röntgenstrukturanalyse Chemie Wirkstoff-Rezeptor-Bindung Isothermal titration calorimetry Inhibitor Aldosereduktase aldose reductase Diabetes mellitus Kalorimetrie Isothermale Titrationskalorimetrie Chemistry & allied sciences
Online Access:	PDF Full Text
Tags:	Add Tag No Tags, Be the first to tag this record!