Charakterisierung des striatalen 6-OHDA-Tiermodells des Morbus Parkinson an der Maus
Strenzke, Corinna
In der vorliegenden Arbeit wurde eines der häufigsten Tiermodelle der Parkinson-Forschung - das striatale 6-OHDA-Modell - im Zeitverlauf über 8 Wochen unter Berücksichtigung von dopaminergem Zellverlust, Dopaminkonzentration, Radikalentstehung als Marker für oxidativen Stress sowie Verhaltensbeeinträchtigungen an der Maus charakterisiert.
Philipps-Universität Marburg
Medical sciences Medicine
urn:nbn:de:hebis:04-z2010-06834
https://doi.org/10.17192/z2010.0683
opus:3212
2010-11-04
Parkinson-Krankheit
urn:nbn:de:hebis:04-z2010-06834
ths
Dr.
Hartmann
Andreas
Hartmann, Andreas (Dr.)
2010-12-02
Characterization of the striatal 6-OHDA model of Parkinsons disease
Parkinsonian Disorders
Philipps-Universität Marburg
Oxidative Stress
Charakterisierung des striatalen 6-OHDA-Tiermodells des Morbus Parkinson an der Maus
Tiermodell
6-OHDA
2011-08-10
Medical sciences Medicine
Medizin
Publikationsserver der Universitätsbibliothek Marburg
Universitätsbibliothek Marburg
In der vorliegenden Arbeit wurde eines der häufigsten Tiermodelle der Parkinson-Forschung - das striatale 6-OHDA-Modell - im Zeitverlauf über 8 Wochen unter Berücksichtigung von dopaminergem Zellverlust, Dopaminkonzentration, Radikalentstehung als Marker für oxidativen Stress sowie Verhaltensbeeinträchtigungen an der Maus charakterisiert.
https://doi.org/10.17192/z2010.0683
Oxidativer Stress
In the present study the striatal 6-OHDA model of Parkinsons disease was characterized in mice with regard to the time-course of dopaminergic cell loss, dopamine concentrations in the substantia nigra and the striatum, hydroxylation products in substantia nigra and striatum as an indicator of oxidative stress behavioural impairment.
Nervenheilkunde
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opus:3212
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6-OHDA
Medizin
Strenzke, Corinna
Strenzke
Corinna
Experimental Neurology.: 210(1): 182-193; 2008
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